Nonalcoholic fatty liver disease (NAFLD) is a prevalent and increasingly diagnosed condition characterized by excessive fat accumulation in the liver. As an emerging global health concern, NAFLD has garnered considerable attention due to its close association with obesity, metabolic syndrome, type 2 diabetes, and other lifestyle-related factors. Typically asymptomatic in its early stages, NAFLD can progress to more serious conditions such as nonalcoholic steatohepatitis (NASH), fibrosis, cirrhosis, or even hepatocellular carcinoma if left untreated. The exact mechanisms underlying the development of NAFLD are complex and multifactorial; however, insulin resistance plays a central role in promoting lipid deposition within hepatocytes.
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