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Quiz on Diagnosing Paroxysmal Nocturnal Hemoglobinuria: What's the Key Test for Confirmation?

Dear doctors, participate in this fun and exciting quiz on diagnostic steps to confirm paroxysmal nocturnal hemoglobinuria. Paroxysmal Nocturnal Hemoglobinuria (PNH) diagnosis relies on flow cytometry to detect the absence of GPI-anchored proteins in blood cells. Early identification is crucial for managing hemolysis, thrombosis, and bone marrow failure associated with this rare hematologic disorder. Participate now.

1. Flow cytometry is the gold standard for diagnosing Paroxysmal Nocturnal Hemoglobinuria (PNH).

2. Paroxysmal Nocturnal Hemoglobinuria is primarily caused by mutations in the GATA1 gene.

3. The absence of CD55 and CD59 on red blood cells leads to intravascular hemolysis in PNH patients.

4. Thrombosis is the leading cause of mortality in patients with Paroxysmal Nocturnal Hemoglobinuria.

5. Eculizumab targets the PIG-A gene mutation in the treatment of PNH.

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